The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …

Although DNA methylation was originally thought to only affect transcription, emerging
evidence shows that it also regulates alternative splicing. Exons, and especially splice sites …

Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …

Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …

Association studies provide genome-wide information about the genetic basis of complex
disease, but medical research has focused primarily on protein-coding variants, owing to the …

DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …

The hypothesis that differences in gene regulation have an important role in speciation and
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …

The burgeoning interest in the field of epigenetics has precipitated the need to develop
approaches to strengthen causal inference when considering the role of epigenetic …

The ability to measure gene expression on a genome-wide scale is one of the most
promising accomplishments in molecular biology. Microarrays, the technology that first …

Exposure to stress early in life permanently shapes activity of the hypothalamic–pituitary–
adrenocortical (HPA) axis and the brain. Prenatally, glucocorticoids pass through the …