Telomerase mechanism of telomere synthesis
RA Wu, HE Upton, JM Vogan… - Annual review of …, 2017 - annualreviews.org
Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus
NF Lue, C Autexier - Nature structural & molecular biology, 2023 - nature.com
Telomerase is a special reverse transcriptase ribonucleoprotein dedicated to the synthesis
of telomere repeats that protect chromosome ends. Among reverse transcriptases …
of telomere repeats that protect chromosome ends. Among reverse transcriptases …
Structure of telomerase with telomeric DNA
Telomerase is an RNA–protein complex (RNP) that extends telomeric DNA at the 3′ ends
of chromosomes using its telomerase reverse transcriptase (TERT) and integral template …
of chromosomes using its telomerase reverse transcriptase (TERT) and integral template …
Telomerase mutations in smokers with severe emphysema
SE Stanley, JJL Chen, JD Podlevsky… - The Journal of …, 2015 - Am Soc Clin Investig
Mutations in the essential telomerase genes TERT and TR cause familial pulmonary fibrosis;
however, in telomerase-null mice, short telomeres predispose to emphysema after chronic …
however, in telomerase-null mice, short telomeres predispose to emphysema after chronic …
InTERTpreting telomerase structure and function
Abstract The Nobel Prize in Physiology or Medicine was recently awarded to Elizabeth
Blackburn, Carol Greider and Jack Szostak for their pioneering studies on chromosome …
Blackburn, Carol Greider and Jack Szostak for their pioneering studies on chromosome …
Structures of telomerase at several steps of telomere repeat synthesis
Telomerase is unique among the reverse transcriptases in containing a noncoding RNA
(known as telomerase RNA (TER)) that includes a short template that is used for the …
(known as telomerase RNA (TER)) that includes a short template that is used for the …
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation
S Panneer Selvam, RM De Palma, JJ Oaks… - Science …, 2015 - science.org
During DNA replication, the enzyme telomerase maintains the ends of chromosomes, called
telomeres. Shortened telomeres trigger cell senescence, and cancer cells often have …
telomeres. Shortened telomeres trigger cell senescence, and cancer cells often have …
Mass transfer in catalytic depolymerization: External effectiveness factors and serendipitous processivity in stagnant and stirred melts
Several heterogeneous catalysts are being developed to recycle plastics. Most operate in
viscous polymer melts, where external mass transfer effects could limit the supply of co …
viscous polymer melts, where external mass transfer effects could limit the supply of co …
Biogenesis of telomerase ribonucleoproteins
ED Egan, K Collins - Rna, 2012 - rnajournal.cshlp.org
Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …
Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions
INTRODUCTION Telomerase is a ribonucleoprotein complex that extends the telomere DNA
at the 3′ ends of linear chromosomes, thereby counteracting the loss of DNA from …
at the 3′ ends of linear chromosomes, thereby counteracting the loss of DNA from …