The epidemiology of amyotrophic lateral sclerosis

EO Talbott, AM Malek, D Lacomis - Handbook of clinical neurology, 2016 - Elsevier
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults and
is characterized by neurodegeneration of motor neurons in the brain and spinal cord. The …

Drosophila as an In Vivo Model for Human Neurodegenerative Disease

L McGurk, A Berson, NM Bonini - Genetics, 2015 - academic.oup.com
With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

[HTML][HTML] Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

VL Feigin, AA Abajobir, KH Abate, F Abd-Allah… - The Lancet …, 2017 - thelancet.com
Background Comparable data on the global and country-specific burden of neurological
disorders and their trends are crucial for health-care planning and resource allocation. The …

The burden of neurological disease in the United States: A summary report and call to action.

CL Gooch, E Pracht, AR Borenstein - Annals of neurology, 2017 - europepmc.org
The burden of neurological disease in the United States: A summary report and call to action. -
Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC Menu About …

[HTML][HTML] Prevalence of amyotrophic lateral sclerosis—United States, 2015

P Mehta - MMWR. Morbidity and mortality weekly report, 2018 - cdc.gov
In 2015, a total of 16,583 persons were identified as having definite ALS. The estimated
prevalence of ALS in 2015 was 5.2 per 100,000 population, which is similar to that in 2014 …

Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study

Y Hu, C Cao, XY Qin, Y Yu, J Yuan, Y Zhao… - Scientific Reports, 2017 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with poorly
understood etiology. Increasing evidence suggest that inflammation may play a critical role …

Correlation of peripheral immunity with rapid amyotrophic lateral sclerosis progression

BJ Murdock, T Zhou, SR Kashlan, RJ Little… - JAMA …, 2017 - jamanetwork.com
Importance Amyotrophic lateral sclerosis (ALS) has an immune component, but previous
human studies have not examined immune changes over time. Objectives To assess …

Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes

J Cady, P Allred, T Bali, A Pestronk, A Goate… - Annals of …, 2015 - Wiley Online Library
Objective To define the genetic landscape of amyotrophic lateral sclerosis (ALS) and assess
the contribution of possible oligogenic inheritance, we aimed to comprehensively sequence …

Association of environmental toxins with amyotrophic lateral sclerosis

FC Su, SA Goutman, S Chernyak, B Mukherjee… - JAMA …, 2016 - jamanetwork.com
Importance Persistent environmental pollutants may represent a modifiable risk factor
involved in the gene-time-environment hypothesis in amyotrophic lateral sclerosis (ALS) …

Potential environmental factors in amyotrophic lateral sclerosis

B Oskarsson, DK Horton… - Neurologic clinics, 2015 - neurologic.theclinics.com
The causes of amyotrophic lateral sclerosis (ALS) are unknown for most patients. ALS is a
clinically defined syndrome where upper and lower motor neurons degenerate, but The …