Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

In the 75 years since the seminal observation of Clive McCay that restriction of calorie intake
extends the lifespan of rats, a great deal has been learned about the effects of calorie …

Maternal obesity is thought to increase the offspring's risk of juvenile obesity and metabolic
diseases; however, the mechanism (s) whereby excess maternal nutrition affects fetal …

The metabolic syndrome (MetS) is one of the most important challenges to public health and
biomedical research. Animal models of MetS, such as leptin‐deficient obese mice, obese …

To begin to understand the contributions of maternal obesity and over-nutrition to human
development and the early origins of obesity, we utilized a non-human primate model to …

Using DNA methylation profiles (n= 15,456) from 348 mammalian species, we constructed
phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using …

Age and sex have a profound effect on cytosine methylation levels in humans and many
other species. Here we analyzed DNA methylation profiles of 2400 tissues derived from 37 …

Intrauterine growth restriction (IUGR) is associated with reduced placental amino acid
transport (AAT). However, it remains to be established if changes in AAT contribute to …

The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

Poor maternal nutrition causes intrauterine growth restriction (IUGR); however, its effects on
fetal cardiac development are unclear. We have developed a baboon model of moderate …