Sex-based differences in human disease are caused in part by the levels of endogenous
sex steroid hormones which regulate mitochondrial metabolism. This review updates a …

Mitochondria are well known as the centre of energy metabolism in eukaryotic cells.
However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative …

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart
failure, and other cardiovascular diseases, as well, but no therapies are available to treat …

Cellular damage produced by conditions generating oxidative stress have far-reaching
implications in human disease that encompass, but are not restricted to aging …

Alzheimer's Disease (AD) is the main cause of dementia and it is defined by cognitive
decline coupled to extracellular deposit of amyloid-beta protein and intracellular …

Mitochondria are cellular organelles which generate adenosine triphosphate (ATP)
molecules for the maintenance of cellular energy through the oxidative phosphorylation …

Abstract Purpose of Review The purpose of this review is to summarize the recently
published scientific literature regarding the effects of mitochondrial function and …

Despite monumental advances in molecular technology to generate genome sequence data
at scale, there is still a considerable proportion of heritability in most complex diseases that …

It is now becoming clear that human metabolism is extremely plastic and varies substantially
between healthy individuals. Understanding the biochemistry that underlies this physiology …

The list of mitochondrial DNA (mtDNA) variants detected in individuals with
neurodegenerative diseases is constantly growing. Evaluating their functional …