The molecular basis of translation initiation and its regulation in eukaryotes
J Brito Querido, I Díaz-López… - Nature Reviews Molecular …, 2024 - nature.com
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …
regulation of gene expression has been studied for several decades, it has been clear over …
How RNA-binding proteins interact with RNA: molecules and mechanisms
M Corley, MC Burns, GW Yeo - Molecular cell, 2020 - cell.com
RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
Endoribonucleolytic cleavage of m6A-containing RNAs by RNase P/MRP complex
Summary N 6-methyladenosine (m 6 A) is the most abundant internal modification in RNAs
and plays regulatory roles in a variety of biological and physiological processes. Despite its …
and plays regulatory roles in a variety of biological and physiological processes. Despite its …
Comprehensive identification of RNA-binding domains in human cells
A Castello, B Fischer, CK Frese, R Horos, AM Alleaume… - Molecular cell, 2016 - cell.com
Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …
these employing unknown modes of RNA binding. We developed RBDmap to determine the …
[HTML][HTML] Pseudouridylation of tRNA-derived fragments steers translational control in stem cells
Pseudouridylation (Ψ) is the most abundant and widespread type of RNA epigenetic
modification in living organisms; however, the biological role of Ψ remains poorly …
modification in living organisms; however, the biological role of Ψ remains poorly …
Inferring protein 3D structure from deep mutation scans
We describe an experimental method of three-dimensional (3D) structure determination that
exploits the increasing ease of high-throughput mutational scans. Inspired by the success of …
exploits the increasing ease of high-throughput mutational scans. Inspired by the success of …
[HTML][HTML] The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation
Initiation is the rate-limiting step in translation, and its dysregulation is vital for
carcinogenesis, including hematopoietic malignancy. Thus, discovery of novel translation …
carcinogenesis, including hematopoietic malignancy. Thus, discovery of novel translation …
Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin
Tristetraprolin (TTP) is an RNA-binding protein that controls the inflammatory response by
limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally …
limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally …
Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly (A)-binding protein
D Melamed, DL Young, CE Gamble, CR Miller, S Fields - Rna, 2013 - rnajournal.cshlp.org
The RNA recognition motif (RRM) is the most common RNA-binding domain in eukaryotes.
Differences in RRM sequences dictate, in part, both RNA and protein-binding specificities …
Differences in RRM sequences dictate, in part, both RNA and protein-binding specificities …
Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery
N Wu, Z Yuan, KY Du, L Fang, J Lyu, C Zhang… - Cell Death & …, 2019 - nature.com
Yap is the key component of Hippo pathway which plays crucial roles in tumorigenesis.
Inhibition of Yap activity could promote apoptosis, suppress proliferation, and restrain …
Inhibition of Yap activity could promote apoptosis, suppress proliferation, and restrain …