Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …

In the last decade, reconstruction and applications of genome-scale metabolic models have
greatly influenced the field of systems biology by providing a platform on which high …

Genome-scale metabolic modeling has become widespread for analyzing microbial
metabolism. Extending this established paradigm to more complex microbial communities is …

Genome-scale metabolic models are increasingly becoming available for a variety of
microorganisms. This has spurred the development of a wide array of computational tools …

Constraint-based modeling (CBM) has evolved as the core systems biology tool to map the
interrelations between genotype, phenotype, and external environment. The recent …

Background Flux coupling analysis (FCA) has become a useful tool in the constraint-based
analysis of genome-scale metabolic networks. FCA allows detecting dependencies between …

Bioinformatics tools have facilitated the reconstruction and analysis of cellular metabolism of
various organisms based on information encoded in their genomes. Characterization of …

Recently there has not been a systematic, objective assessment of the metabolic capabilities
of the human platelet. A manually curated, functionally tested and validated biochemical …

Metabolic network analysis based on stoichiometric and constraint-based methods has
become one of the most popular and successful modeling approaches in network and …

Microorganisms are ubiquitous and adapt to various dynamic environments to sustain
growth. These adaptations accumulate, generating new traits forming the basis of evolution …