Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Intestines are organs that not only digest food and absorb nutrients, but also provide a
defense barrier against pathogens and noxious agents ingested. Tight junctions (TJs) are …

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel
Foods and Food Allergens (NDA) derived dietary reference values (DRV s) for sodium …

Calcium (Ca2+) homeostasis is maintained through coordination between intestinal
absorption, renal reabsorption, and bone remodeling. Intestinal and renal (re) absorption …

Central to the maintenance of calcium homeostasis is the regulated reabsorption of calcium
along the nephron. To this end, parathyroid hormone (PTH) is released from the parathyroid …

The SLC9 gene family encodes Na+/H+ exchangers (NHEs). These transmembrane
proteins transport ions across lipid bilayers in a diverse array of species from prokaryotes to …

Hyperphosphatemia is common in patients with chronic kidney disease and is increasingly
associated with poor clinical outcomes. Current management of hyperphosphatemia with …

Nephrolithiasis is a worldwide problem with increasing prevalence, enormous costs, and
significant morbidity. Calcium-containing kidney stones are by far the most common kidney …

The role of the kidney in calcium homeostasis has been reshaped from a classic view in
which the kidney was regulated by systemic calcitropic hormones such as vitamin D3 or …

Kidney stones are a prevalent clinical condition imposing a large economic burden on the
healthcare system. Hypercalciuria remains the major risk factor for development of a Ca2+ …