[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry
F Pognan, M Beilmann, H Boonen, A Czich… - Nature reviews drug …, 2023 - nature.com
For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …
treatment-related effects were carefully reported and used as a basis to calculate safety …
Current challenges of iPSC-based disease modeling and therapeutic implications
MX Doss, A Sachinidis - Cells, 2019 - mdpi.com
Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …
therapy approach have proven to be very powerful and instrumental in biomedical research …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity
DJ Richards, Y Li, CM Kerr, J Yao, GC Beeson… - Nature biomedical …, 2020 - nature.com
Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …
Induced pluripotent stem cell technology: a decade of progress
Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago,
enormous progress has been made in stem cell biology and regenerative medicine. Human …
enormous progress has been made in stem cell biology and regenerative medicine. Human …
Single-cell RNA sequencing in cardiovascular development, disease and medicine
Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …
have had a transformative effect on biomedical research, enabling the profiling and analysis …
Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility
Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
Wnt activation and reduced cell-cell contact synergistically induce massive expansion of functional human iPSC-derived cardiomyocytes
Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …
Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips
The immature physiology of cardiomyocytes derived from human induced pluripotent stem
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …
Engineering cardiac muscle tissue: a maturating field of research
F Weinberger, I Mannhardt, T Eschenhagen - Circulation research, 2017 - Am Heart Assoc
Twenty years after the initial description of a tissue engineered construct, 3-dimensional
human cardiac tissues of different kinds are now generated routinely in many laboratories …
human cardiac tissues of different kinds are now generated routinely in many laboratories …