Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of
dopaminergic neurons in the substantia nigra pars compacta (SN c). Alpha‐synuclein …

The self-assembly of α-synuclein (αS) into intraneuronal inclusion bodies is a key
characteristic of Parkinson's disease. To define the nature of the species giving rise to …

Oligomeric species populated during the aggregation process of α-synuclein have been
linked to neuronal impairment in Parkinson's disease and related neurodegenerative …

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological
toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP …

Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …

Protein aggregation and abnormal lipid homeostasis are both implicated in
neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate …

Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the
main pathological drivers in the disease, although it remains unclear how this protein elicits …

Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Protein misfolding is a general hallmark of protein deposition diseases, such as Alzheimer's
disease or Parkinson's disease, in which different types of aggregated species (oligomers …