Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …

Owing to the efficacy in reducing pain and inflammation, non-steroidal anti-inflammatory
drugs (NSAIDs) are amongst the most popularly used medicines confirming their position in …

This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action
of eicosanoids in different physiological systems, the roles of eicosanoids in selected …

Simple Summary Inflammation is assessed as a hallmark of cancer and it is now widely
recognized that there exists a direct causal link between inflammation and tumors. Among …

The chemistry, biochemistry, pharmacology and molecular biology of oxylipins (defined as a
family of oxygenated natural products that are formed from unsaturated fatty acids by …

Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various
biological processes, including immune response, inflammation, cell growth and survival …

Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …

High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …

Apigenin (4′, 5, 7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …

Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …