Bone undergoes continuous remodeling, which is homeostatically regulated by concerted
communication between bone-forming osteoblasts and bone-degrading osteoclasts …

There are many downstream targets of mitogen-activated protein kinase (MAPK) signalling
that are involved in neuronal development, cellular differentiation, cell migration, cancer …

Objectives The main target of current drugs for alleviating bone loss is osteoclasts. However,
the long‐term application of such drugs will also cause side effects. Therefore, it is of great …

Graphene Oxide (GO)-related hydrogels have been extensively studied in hard tissue repair,
because GO can not only enhance the mechanical properties of polymers but also promote …

Osteocalcin, also known as bone γ-carboxyglutamate protein (Bglap), is expressed by
osteoblasts and is commonly used as a clinical marker of bone turnover. A mouse model of …

Multiple myeloma (MM) is a hematological malignancy, which remains incurable because
most patients eventually relapse or become refractory to current treatments. Due to …

Integrity of the skeleton is sustained through the balanced activities of osteoblasts and
osteoclasts in bone remodeling unit. The balance can be disrupted by excessive osteoclasts …

The achievement of proper bone mass and architecture, and their maintenance throughout
life requires the concerted actions of osteoblasts, the bone forming cells, and osteoclasts …

It is well known that extensive osteoclast formation plays a key role in osteoporosis in post‑
menopausal women and the elderly. The suppression of extensive osteoclastogenesis and …

As the global population ages, bone diseases have become increasingly prevalent in
clinical settings. These conditions often involve detrimental factors such as infection …