RNA interference (RNAi) was discovered at the end of last millennium, changing the way
scientists understood regulation of gene expression. Within the following two decades, a …

Highlights•Examples of transgenerational epigenetic inheritance of brain related
phenotypes.•Overview of putative molecular carriers of non-genetic information are …

Micronuclei (MN) are cytosolic bodies that sequester acentric fragments or mis-segregated
chromosomes from the primary nucleus. Spontaneous rupture of the MN envelope allows …

The mobility of transposable elements (TEs) contributes to evolution of genomes. Their
uncontrolled activity causes genomic instability; therefore, expression of TEs is silenced by …

Faithful transfer of parental histones to newly replicated daughter DNA strands is critical for
inheritance of epigenetic states. Although replication proteins that facilitate parental histone …

DNA modifications are used to regulate gene expression and defend against invading
genetic elements. In eukaryotes, modifications predominantly involve C5-methylcytosine …

Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders
embedded genes transcriptionally silent,–. In the fission yeast Schizosaccharomyces …

Histone post-translational modifications (PTMs) are associated with epigenetic states that
form the basis for cell-type-specific gene expression,. Once established, histone PTMs can …

Chromodomain helicase DNA-binding protein 7 (CHD7), an ATP-dependent eukaryotic
chromatin remodeling enzyme, is essential for the development of organs. The mutation of …

Spatially and functionally distinct domains of heterochromatin and euchromatin play
important roles in the maintenance of chromosome stability and regulation of gene …