Cancer stem cells (CSCs) are self-renewing cells that facilitate tumor initiation, promote
metastasis, and enhance cancer therapy resistance. Transcriptomic analyses across many …

Glioblastoma (GBM) is the most belligerent and frequent brain tumor in adults. Research
over the past two decades has provided increased knowledge of the genomic and molecular …

Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …

Tumor-associated macrophage (TAM) phagocytic activity is emerging as a new mechanism
to harness for cancer treatment. Currently, many approaches are investigated at the …

Abstract ABSTRACT: Colony-Stimulating Factor-1 Receptor (CSF1R) is a receptor tyrosine
kinase that controls the differentiation and maintenance of most tissue-resident …

Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we
found that ICBs induce cerebral edema in some patients and mice with glioblastoma …

Simple Summary Patients with glioblastoma—the most frequent and malignant primary brain
tumor—have a poor prognosis with a median survival of less than 15 months. Despite …

Glioblastoma is the most common and aggressive primary malignant brain tumour. The
prognosis of patients with glioblastoma is poor, and their overall survival averages at 1 year …

The symbiotic interactions between cancer stem cells and the tumor microenvironment
(TME) are critical for tumor progression. However, the molecular mechanism underlying this …

High-grade glioma is one of the deadliest primary tumors of the central nervous system.
Despite the many novel immunotherapies currently in development, it has been difficult to …