WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

In response to injury, hemodynamic changes, or neurohormonal activation, the heart
undergoes a series of structural and functional changes that have been termed cardiac …

Objective Despite previous research that focused on liver transaminases as predictors of
cardiovascular disease, there has been limited research evaluating the predictive value of …

In patients with heart failure, the beneficial effects of drug and device therapies counteract to
some extent ongoing cardiac damage. According to the net balance between these two …

Myocardial fibrosis is the result of excessive fibrillar collagen synthesis and deposition
without reciprocally balanced degradation. It causes cardiac dysfunction, arrhythmias, and …

Background—Heart failure with preserved ejection fraction is a clinical syndrome that has
been associated with changes in the extracellular matrix. The purpose of this study was to …

Extracellular matrix remodeling is extensive in several heart diseases and hampers cardiac
filling, often leading to heart failure. Proteoglycans have over the last two decades emerged …

Cardiotoxicity resulting from direct myocyte damage has been a known complication of
cancer treatment for decades. More recently, the emergence of hypertension as a clinically …

Small leucine‐rich proteoglycans are emerging as important regulatory proteins within the
extracellular matrix, where they exert both structural and nonstructural functions and hence …

Anti-neoplastic chemotherapy can determine various side effects, including cardiotoxicity,
and no real guidelines for its early detection and management have been developed. The …