Lipid metabolites are emerging as pivotal regulators of protein function and cell signaling.
The availability of intracellular fatty acid is tightly regulated by glycolipid metabolism and …

Parkinson's disease is characterised by the presence in brain tissue of aberrant inclusions
known as Lewy bodies and Lewy neurites, which are deposits composed by α-synuclein …

Synaptotagmin-11 (Syt11) is a vesicle-trafficking protein that is linked genetically to
Parkinson's disease (PD). Likewise, the protein α-synuclein regulates vesicle trafficking, and …

Huntington disease (HD) damages the corticostriatal circuitry in large part by impairing
transport of brain-derived neurotrophic factor (BDNF). We hypothesized that improving …

Parkinson's disease (PD) is characterized by conversion of soluble α-synuclein (αS) into
intraneuronal aggregates and degeneration of neurons and neuronal processes. Indications …

α-Synuclein plays a key role in the pathogenesis of Parkinson's disease and related
disorders, but critical interacting partners and molecular mechanisms mediating …

Posttranslational modifications increase the complexity and functional diversity of proteins in
response to complex external stimuli and internal changes. Among these, protein lipidations …

Idiopathic Parkinson's disease is the second most common neurodegenerative disease and
is estimated to be approximately 30% heritable. Genome wide association studies have …

Stearoyl-CoA desaturase (SCD) is a potential therapeutic target for Parkinson's and related
neurodegenerative diseases. SCD inhibition ameliorates neuronal toxicity caused by …

The relationship between Parkinson's disease (PD), the second-most common
neurodegenerative disease after Alzheimer's disease, and palmitoylation, a post …