Risk of cardiovascular disease and mortality in young adults with end-stage renal disease: an analysis of the US renal data system
ZJ Modi, Y Lu, N Ji, A Kapke, DT Selewski… - JAMA …, 2019 - jamanetwork.com
Importance Cardiovascular disease (CVD) is a leading cause of death among patients with
end-stage renal disease (ESRD). Young adult (ages 22-29 years) have risks for ESRD …
end-stage renal disease (ESRD). Young adult (ages 22-29 years) have risks for ESRD …
APOL1 genotype and renal function of black living donors
MD Doshi, M Ortigosa-Goggins, AX Garg… - Journal of the …, 2018 - journals.lww.com
Black living kidney donors are at higher risk of developing kidney disease than white
donors. We examined the effect of the APOL1 high-risk genotype on postdonation renal …
donors. We examined the effect of the APOL1 high-risk genotype on postdonation renal …
APOL1 nephropathy: a population genetics and evolutionary medicine detective story
E Kruzel-Davila, WG Wasser, K Skorecki - Seminars in nephrology, 2017 - Elsevier
Common DNA sequence variants rarely have a high-risk association with a common
disease. When such associations do occur, evolutionary forces must be sought, such as in …
disease. When such associations do occur, evolutionary forces must be sought, such as in …
[HTML][HTML] APOL1 risk variants and kidney disease: what we know so far
There are striking differences in chronic kidney disease between Caucasians and African
descendants. It was widely accepted that this occurred due to socioeconomic factors, but …
descendants. It was widely accepted that this occurred due to socioeconomic factors, but …
Kidney disease-associated APOL1 variants have dose-dependent, dominant toxic gain-of-function
Background Two coding renal risk variants (RRVs) of the APOL1 gene (G1 and G2) are
associated with large increases in CKD rates among populations of recent African descent …
associated with large increases in CKD rates among populations of recent African descent …
[HTML][HTML] The kidney evaluation of living kidney donor candidates: US practices in 2017
We surveyed US transplant programs to assess practices used to assess kidney health in
living kidney donor candidates in 2017; the response rate was 31%. In this report, we focus …
living kidney donor candidates in 2017; the response rate was 31%. In this report, we focus …
APOL1 Risk Variants and Cardiovascular Disease: Results From the AASK (African American Study of Kidney Disease and Hypertension)
Objective—Among African Americans, the apolipoprotein L1 (APOL1) risk variants have
been associated with various types of kidney disease and chronic kidney disease …
been associated with various types of kidney disease and chronic kidney disease …
APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults
OM Gutiérrez, MR Irvin, NS Chaudhary… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: APOL1 renal risk variants are strongly associated with chronic kidney disease
in Black adults, but reported associations with cardiovascular disease (CVD) have been …
in Black adults, but reported associations with cardiovascular disease (CVD) have been …
[HTML][HTML] Strict blood pressure control associates with decreased mortality risk by APOL1 genotype
Although APOL1 high-risk genotype partially accounts for the increased susceptibility of
blacks to chronic kidney disease (CKD), whether APOL1 associates differentially with …
blacks to chronic kidney disease (CKD), whether APOL1 associates differentially with …
[HTML][HTML] APOL1 renal-risk variants do not associate with incident cardiovascular disease or mortality in the Systolic Blood Pressure Intervention Trial
BI Freedman, MV Rocco, JT Bates, M Chonchol… - Kidney international …, 2017 - Elsevier
Introduction Relationships between apolipoprotein L1 gene (APOL1) renal-risk variants
(RRVs) and cardiovascular disease (CVD) remain controversial. To clarify associations …
(RRVs) and cardiovascular disease (CVD) remain controversial. To clarify associations …