Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …

Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …

Background Disturbance in the equilibrium of the gut microbiota has been involved in the
pathophysiology of depression. Probiotics have the potential to healthfully modulate the gut …

Organisms evolve in response to their natural environment. Consideration of natural
ecological parameters are thus of key importance for our understanding of an organism's …

Most Caenorhabditis elegans studies have used laboratory Escherichia coli as diet and
microbial environment. Here we characterize bacteria of C. elegans' natural habitats of …

The study of microbiomes by sequencing has revealed a plethora of correlations between
microbial community composition and various life-history characteristics of the …

The microbial mechanisms and key metabolites that shape the composition of the human
gut microbiota are largely unknown, impeding efforts to manipulate dysbiotic microbial …

Changes in the microbiota are associated with alterations in nervous system structure-
function and behavior and have been implicated in the etiology of neuropsychiatric and …

Recent discoveries have implicated the gut microbiome in the progression and severity of
Parkinson's disease; however, how gut bacteria affect such neurodegenerative disorders …