Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy
BA Fang, Ž Kovačević, KC Park, DS Kalinowski… - … et Biophysica Acta (BBA …, 2014 - Elsevier
N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple
cancers, being also involved in embryogenesis and development, cell growth and …
cancers, being also involved in embryogenesis and development, cell growth and …
Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer
KC Park, J Paluncic, Z Kovacevic… - Free Radical Biology and …, 2020 - Elsevier
N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that is
regulated by hypoxia, metal ions including iron, the free radical nitric oxide (NO.), and …
regulated by hypoxia, metal ions including iron, the free radical nitric oxide (NO.), and …
TF-DUBTACs stabilize tumor suppressor transcription factors
Targeted protein degradation approaches have been widely used for degrading oncogenic
proteins, providing a potentially promising therapeutic strategy for cancer treatment …
proteins, providing a potentially promising therapeutic strategy for cancer treatment …
The levels of hypoxia-regulated microRNAs in plasma of pregnant women with fetal growth restriction
JF Mouillet, T Chu, CA Hubel, DM Nelson, WT Parks… - Placenta, 2010 - Elsevier
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-
transcriptional level. While mostly intracellular, a portion of cellular miRNAs is released to …
transcriptional level. While mostly intracellular, a portion of cellular miRNAs is released to …
Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration
In Duchenne muscular dystrophy (DMD), the absence of the dystrophin protein causes a
variety of poorly understood secondary effects. Notably, muscle fibers of dystrophic …
variety of poorly understood secondary effects. Notably, muscle fibers of dystrophic …
New insights into protein hydroxylation and its important role in human diseases
Protein hydroxylation is a post-translational modification catalyzed by 2-oxoglutarate-
dependent dioxygenases. The hydroxylation modification can take place on various amino …
dependent dioxygenases. The hydroxylation modification can take place on various amino …
T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells
KL Redmond, NT Crawford, H Farmer, ZC D'costa… - Oncogene, 2010 - nature.com
Abstract T-box 2 (TBX2) is a transcription factor involved in mammary development and is
known to be overexpressed in a subset of aggressive breast cancers. TBX2 has previously …
known to be overexpressed in a subset of aggressive breast cancers. TBX2 has previously …
MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo
Background Vascular shear stress promotes endothelial cell sprouting in vitro. The impact of
hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular …
hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular …
[HTML][HTML] LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene
Neuroblastoma (NB) with MYCN amplification is a highly aggressive and metastatic tumor in
children. The high recurrence rate and resistance of NB cells to drugs urgently demands a …
children. The high recurrence rate and resistance of NB cells to drugs urgently demands a …
DNA methylation patterns as noninvasive biomarkers and targets of epigenetic therapies in colorectal cancer
Aberrant DNA methylation is frequently detected in gastrointestinal tumors, and can
therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …
therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …