Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …

ABSTRACT Introduction: Acetyl-CoA Carboxylase (ACC) is an essential rate-limiting
enzyme in fatty acid metabolism. For many years, ACC inhibitors have gained great attention …

An organophotoredox-catalyzed decarboxylative cross-coupling between azole
nucleophiles and aliphatic carboxylic acid-derived redox-active esters is demonstrated. This …

The fusion of pyrazole scaffold with other skeletons creates a class of attractive molecules,
demonstrating significant biological and chemical potentiality in the development of …

The Curtius rearrangement is the thermal decomposition of an acyl azide derived from
carboxylic acid to produce an isocyanate as the initial product. The isocyanate can undergo …

Condensed pyrazole derivatives are important heterocyclic compounds due to their
excellent biological activities and have been widely applied in pharmaceutical and …

A series of novel pyrazole-phenyl semicarbazone derivatives were designed, synthesized,
and screened for in vitro α-glucosidase inhibitory activity. Given the importance of hydrogen …

In this work, new derivatives of biphenyl pyrazole-benzofuran hybrids were designed,
synthesized and evaluated in vitro through enzymatic assay for inhibitory effect against α …

The α‐glucosidase is a validated target to develop drugs for treating type 2 diabetes
mellitus. The existing α‐glucosidase inhibitors have certain shortcomings related to side …

The development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic
disease has been pursued by the pharmaceutical industry for some time. A number of recent …