Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …

A detailed understanding of the mechanisms that establish or maintain the latent reservoir of
HIV will guide approaches to eliminate persistent infection. We used a cell line and primary …

Background Visceral leishmaniasis (VL) is characterized by parasite-specific
immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide …

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and
counterregulator of glucocorticoids, is a potential therapeutic target. MIF is markedly different …

Introduction: Within the inflammatory immune response to viral infection, the distribution and
cell type-specific profiles of immune cell populations and the immune-mediated viral …

The macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that recently
emerged as an attractive therapeutic target for a variety of diseases. A diverse panel of fully …

Extracellular human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is a
pleiotropic protein accomplishing several functions within the viral life cycle. While Vpr has …

Understanding the mechanisms by which Entamoeba histolytica drives gut inflammation is
critical for the development of improved preventive and therapeutic strategies. E. histolytica …

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory and tumor-promoting
cytokine that occurs in two redox-dependent immunologically distinct conformational …