Macrophage migration inhibitory factor (MIF): a multifaceted cytokine regulated by genetic and physiological strategies
K Sumaiya, D Langford, K Natarajaseenivasan… - Pharmacology & …, 2022 - Elsevier
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …
The multifaceted roles of NLRP3-modulating proteins in virus infection
The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
[HTML][HTML] Single-cell analysis of quiescent HIV infection reveals host transcriptional profiles that regulate proviral latency
T Bradley, G Ferrari, BF Haynes, DM Margolis… - Cell reports, 2018 - cell.com
A detailed understanding of the mechanisms that establish or maintain the latent reservoir of
HIV will guide approaches to eliminate persistent infection. We used a cell line and primary …
HIV will guide approaches to eliminate persistent infection. We used a cell line and primary …
Evidence that lipopolisaccharide may contribute to the cytokine storm and cellular activation in patients with visceral leishmaniasis
JR Santos-Oliveira, EG Regis, CRB Leal… - PLoS neglected …, 2011 - journals.plos.org
Background Visceral leishmaniasis (VL) is characterized by parasite-specific
immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide …
immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide …
[HTML][HTML] Selective targeting of a disease-related conformational isoform of macrophage migration inhibitory factor ameliorates inflammatory conditions
M Thiele, RJ Kerschbaumer, FWK Tam… - The Journal of …, 2015 - journals.aai.org
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and
counterregulator of glucocorticoids, is a potential therapeutic target. MIF is markedly different …
counterregulator of glucocorticoids, is a potential therapeutic target. MIF is markedly different …
A single-cell atlas reveals shared and distinct immune responses and metabolic profiles in SARS-CoV-2 and HIV-1 infections
Introduction: Within the inflammatory immune response to viral infection, the distribution and
cell type-specific profiles of immune cell populations and the immune-mediated viral …
cell type-specific profiles of immune cell populations and the immune-mediated viral …
Neutralization of macrophage migration inhibitory factor (MIF) by fully human antibodies correlates with their specificity for the β-sheet structure of MIF
RJ Kerschbaumer, M Rieger, D Völkel, D Le Roy… - Journal of Biological …, 2012 - ASBMB
The macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that recently
emerged as an attractive therapeutic target for a variety of diseases. A diverse panel of fully …
emerged as an attractive therapeutic target for a variety of diseases. A diverse panel of fully …
Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival
A Ferrucci, MR Nonnemacher, B Wigdahl - Journal of neurovirology, 2013 - Springer
Extracellular human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is a
pleiotropic protein accomplishing several functions within the viral life cycle. While Vpr has …
pleiotropic protein accomplishing several functions within the viral life cycle. While Vpr has …
Entamoeba histolytica–Encoded Homolog of Macrophage Migration Inhibitory Factor Contributes to Mucosal Inflammation during Amebic Colitis
Understanding the mechanisms by which Entamoeba histolytica drives gut inflammation is
critical for the development of improved preventive and therapeutic strategies. E. histolytica …
critical for the development of improved preventive and therapeutic strategies. E. histolytica …
Role of the cysteine 81 residue of macrophage migration inhibitory factor as a molecular redox switch
A Schinagl, RJ Kerschbaumer, N Sabarth… - Biochemistry, 2018 - ACS Publications
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory and tumor-promoting
cytokine that occurs in two redox-dependent immunologically distinct conformational …
cytokine that occurs in two redox-dependent immunologically distinct conformational …