Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

A growing body of evidence indicates that, over the course of evolution of the immune
system, arginine has been selected as a node for the regulation of immune responses. An …

Although creatine has been mostly studied as an ergogenic aid for exercise, training, and
sport, several health and potential therapeutic benefits have been reported. This is because …

Rationale: Emerging evidence indicates that the growth of blood vessels and osteogenesis
is tightly coordinated during bone development. However, the molecular regulators of …

Perturbations in metabolic processes are associated with diseases such as obesity, type 2
diabetes mellitus, certain infections and some cancers. A resurgence of interest in creatine …

The coordination of immunity across organs is fundamental to cancer development and
progression. It is well known that the hostile metabolic microenvironment in the tumour is a …

Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the
immunosuppressive tumor microenvironment and improve cancer immunotherapy …

Cellular metabolism constitutes a fundamental process in biology. During tumor initiation
and progression, each cellular component in the cancerous niche undergoes dramatic …

As one of the most popular nutrient supplements, creatine has been highly used to increase
muscle mass and improve exercise performance. Here, we report an adverse effect of …

Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we
hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify …