Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism

S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

Treating organophosphates poisoning: management challenges and potential solutions

M Alozi, M Rawas-Qalaji - Critical reviews in toxicology, 2020 - Taylor & Francis
Organophosphorus agents (OP) are widely used as pesticides due to their cost
effectiveness, yet they present a significant public health risk owing to their high toxicity …

Review of possible therapies in treatment of Novichoks poisoning and HAZMAT/CBRNE approaches: state of the art

M Noga, A Michalska, K Jurowski - Journal of Clinical Medicine, 2023 - mdpi.com
Novichoks-organophosphorus compounds belong to the nerve agents group, constituting
the fourth generation of chemical warfare agents. The tremendous toxicity of Novichoks is …

[PDF][PDF] Chemical properties, biological activities and poisoning treatment of Novichok: A review

TA Rahmania, BWK Wardhani… - J. Pharm. Sci …, 2021 - pdfs.semanticscholar.org
Novichok is an organophosphate compound found as a nerve agent chemical weapon.
However, the information about its chemical properties, biological activities, and molecular …

[HTML][HTML] Development and characterization of an automated behavioral assessment platform for the Göttingen minipig

JL Langston, TM Myers - Toxicology Letters, 2024 - Elsevier
The Göttingen minipig is fast becoming the standard for assessing dermal chemical hazards
because, like most swine, its skin is predictive of human skin response and because this …

A complete, evidence-based review on novichok poisoning based on epidemiological aspects and clinical management

A Charejoo, M Arabfard, A Jafari, YH Nourian - Frontiers in toxicology, 2023 - frontiersin.org
Background: The whole world has learned about the existence of a highly toxic neuro-
paralytic substance called Novichok. A wide range of neuro-paralytic toxins were used …

Conjugates of human serum butyrylcholinesterase and nerve agents are behaviorally safe in rhesus macaques

A Saxena, TM Myers, ML Sipos - Chemico-Biological Interactions, 2021 - Elsevier
Exogenously administered human serum butyrylcholinesterase (Hu BChE) affords
protection by binding to organophosphorus (OP) nerve agents and pesticides in circulation …

Перспективы применения скавенджеров в качестве средств антидотной терапии острых отравлений веществами антихолинэстеразного действия (обзор …

АМ Свентицкая, АБ Орлова, СН Субботина… - Medline. ru …, 2020 - elibrary.ru
В обзоре рассмотрены подходы к профилактике и лечению отравлений веществам с
анихолинестеразным действием фосфорорганической структуры (ФОС), связанные с …

Understanding the bioconjugation reaction of phenthoate with human serum albumin: New insights from experimental and computational approaches

F Ding, W Peng, YK Peng, BQ Liu - Toxicology Letters, 2019 - Elsevier
Organophosphates are chemical pollutants that are existed widely in the environment, but
the reactions of these agents with blood proteins are still not fully clarified. The current story …

Sintesi di nuove N-(acil)-2-metossifenotiazine quali potenziali inibitori della Butirrilcolinesterasi

P Schenone - 2021 - unire.unige.it
Negli ultimi anni la butirrilcolinesterasi (BChE) ha assunto importanza in campo
farmaceutico. Nell'introduzione sono trattate le informazioni strutturali della BChE e delle …