Biological roles of adenine methylation in RNA
K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
The role of m6A modification in the biological functions and diseases
X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
Reading, writing and erasing mRNA methylation
S Zaccara, RJ Ries, SR Jaffrey - Nature reviews Molecular cell biology, 2019 - nature.com
RNA methylation to form N 6-methyladenosine (m6A) in mRNA accounts for the most
abundant mRNA internal modification and has emerged as a widespread regulatory …
abundant mRNA internal modification and has emerged as a widespread regulatory …
Single-base mapping of m6A by an antibody-independent method
N 6-methyladenosine (m6A) is one of the most abundant messenger RNA modifications in
eukaryotes involved in various pivotal processes of RNA metabolism. The most popular high …
eukaryotes involved in various pivotal processes of RNA metabolism. The most popular high …
Deciphering epitranscriptome: modification of mRNA bases provides a new perspective for post-transcriptional regulation of gene expression
S Kumar, T Mohapatra - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Gene regulation depends on dynamic and reversibly modifiable biological and chemical
information in the epigenome/epitranscriptome. Accumulating evidence suggests that …
information in the epigenome/epitranscriptome. Accumulating evidence suggests that …
Detection technologies for RNA modifications
Y Zhang, L Lu, X Li - Experimental & Molecular Medicine, 2022 - nature.com
To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
A metabolic labeling method detects m6A transcriptome-wide at single base resolution
X Shu, J Cao, M Cheng, S Xiang, M Gao, T Li… - Nature chemical …, 2020 - nature.com
Transcriptome-wide mapping of N 6-methyladenosine (m6A) at base resolution remains an
issue, impeding our understanding of m6A roles at the nucleotide level. Here, we report a …
issue, impeding our understanding of m6A roles at the nucleotide level. Here, we report a …
Modified nucleic acids: replication, evolution, and next-generation therapeutics
K Duffy, S Arangundy-Franklin, P Holliger - Bmc Biology, 2020 - Springer
Modified nucleic acids, also called xeno nucleic acids (XNAs), offer a variety of advantages
for biotechnological applications and address some of the limitations of first-generation …
for biotechnological applications and address some of the limitations of first-generation …
N6‐methyladenosine regulatory machinery in plants: composition, function and evolution
H Yue, X Nie, Z Yan, S Weining - Plant Biotechnology Journal, 2019 - Wiley Online Library
Summary N6‐methyladenosine (m6A) RNA methylation, one of the most pivotal internal
modifications of RNA, is a conserved post‐transcriptional mechanism to enrich and regulate …
modifications of RNA, is a conserved post‐transcriptional mechanism to enrich and regulate …