Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Classical dendritic cells (cDC) are professional antigen-presenting cells (APC) that regulate
immunity and tolerance. Neutrophil-derived cells with properties of DCs (nAPC) are …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

The systemic immune response to viral infection is shaped by master transcription factors,
such as NF-κB, STAT1, or PU. 1. Although long noncoding RNAs (lncRNAs) have been …

Transcriptional regulators, including the cohesin complex member STAG2, are recurrently
mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor …

Impairment of microglial clearance activity contributes to beta-amyloid (Aβ) pathology in
Alzheimer's disease (AD). While the transcriptome profile of microglia directs microglial …

Transcription factor (TF) DNA-binding dynamics govern cell fate and identity. However, our
ability to pharmacologically control TF localization is limited. Here we leverage chemically …

Macrophages are key innate immune cells in the tumor microenvironment (TME) that
regulate primary tumor growth, vascularization, metastatic spread and tumor response to …

Pervasive neuroinflammation occurs in many neurodegenerative diseases, including
Alzheimer's disease (AD). SPI1/PU. 1 is a transcription factor located at a genome-wide …