Macrophages undergo profound metabolic reprogramming upon sensing infectious and
sterile stimuli. This metabolic shift supports and regulates essential innate immune functions …

Patients with type-2 diabetes (T2D) are more likely to develop severe respiratory tract
infections. Such susceptibility has gained increasing attention since the global spread of …

Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

To replicate inside macrophages and cause tuberculosis, Mycobacterium tuberculosis must
scavenge a variety of nutrients from the host,. The mammalian cell entry (MCE) proteins are …

We present an in‐depth analysis of selected CASP15 targets, focusing on their biological
and functional significance. The authors of the structures identify and discuss key protein …

The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the
cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ …

Lipids are complex organic molecules that fulfill energy demands and sometimes act as
signaling molecules. They are mostly found in membranes, thus playing an important role in …

Mycobacterium tuberculosis (Mtb) hijacks host-derived fatty acids (FAs) to sustain its
intracellular growth inside host cells. Here, we present a click-chemistry-based protocol to …

Background: The innate immune system is the first line of defense against microbial
pathogens and is essential for maintaining good health. If pathogens breach innate barriers …

Abstract Mycobacterium tuberculosis (Mtb) reprograms FAs metabolism of macrophages
during infection and affects inflammatory reaction eventually, however, the mechanism …