Extrapyramidal movement disorders include hypokinetic rigid and hyperkinetic or mixed
forms, most of them originating from dysfunction of the basal ganglia (BG) and their …

Despite an early understanding of amyotrophic lateral sclerosis (ALS) as a disease affecting
the motor system, including motoneurons in the motor cortex, brainstem, and spinal cord …

The most frequent neurodegenerative proteinopathies include diseases with deposition of
misfolded tau or α-synuclein in the brain. Pathological protein aggregates in the PNS are …

Two subtypes of progressive apraxia of speech (PAOS) have been recognized: phonetic
PAOS (PAOS_ph) where speech output is dominated by distorted sound substitutions and …

Background: Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) are
examples of neurodegenerative diseases, characterized by abnormal tau inclusions, that …

The central nervous system (CNS) is a complex network of components that allow an
organism to interact with its environment. It is made up of multiple different parts, each of …

Introduction. Primary progressive aphasia (PPA) is a clinically variable syndrome
manifesting as slow progressive loss of speech and language with multiple underlying …

Background Microstructural white matter integrity captured by diffusion-tensor imaging (DTI)
is significantly more affected in progressive supranuclear palsy-Richardson's syndrome …

Background Microstructural alterations of corticospinal tract (CST) have been found in
idiopathic normal pressure hydrocephalus (iNPH). No study, however, investigated the effect …

Nerve growth factor (NGF) has been shown to support the survival and differentiation of
neurons. In this study, we first developed a retrograde trans-multisynaptic tracer PRV580 …