Palliative care and end-of-life care in adults with malignant brain tumors

JAF Koekkoek, PB van der Meer, A Pace… - Neuro …, 2023 - academic.oup.com
Background This systematic review provides updated insights, from the published literature
in the past 5 years, based on the 2017 European Association of Neuro-Oncology (EANO) …

[HTML][HTML] Valproate and lithium: Old drugs for new pharmacological approaches in brain tumors?

G Natale, E Fini, PF Calabrò, M Carli, M Scarselli… - Cancer Letters, 2023 - Elsevier
Beyond its use as an antiepileptic drug, over time valproate has been increasingly used for
several other therapeutic applications. Among these, the antineoplastic effects of valproate …

Postoperative risk of IDH-mutant glioma–associated seizures and their potential management with IDH-mutant inhibitors

MR Drumm, W Wang, TK Sears… - The Journal of …, 2023 - Am Soc Clin Investig
Seizures are a frequent complication of adult-type diffuse gliomas, and are often difficult to
control with medications. Gliomas with mutations in isocitrate dehydrogenase 1 or 2 …

Management of epilepsy in brain tumor patients

PB Van der Meer, MJB Taphoorn… - Current opinion in …, 2022 - journals.lww.com
Management of epilepsy in brain tumor patients : Current Opinion in Oncology Management
of epilepsy in brain tumor patients : Current Opinion in Oncology Log in or Register Subscribe …

First‐line levetiracetam versus enzyme‐inducing antiseizure medication in glioma patients with epilepsy

PB van der Meer, M Maschio, L Dirven… - …, 2023 - Wiley Online Library
Objective This study aimed to directly compare the effectiveness of first‐line monotherapy
levetiracetam (LEV) versus enzyme‐inducing antiseizure medications (EIASMs) in glioma …

Prescription preferences of antiepileptic drugs in brain tumor patients: an international survey among EANO members

PB van der Meer, L Dirven… - Neuro-Oncology …, 2022 - academic.oup.com
Background This study aimed at investigating antiepileptic drug (AED) prescription
preferences in patients with brain tumor-related epilepsy (BTRE) among the European …

Antitumor potential of antiepileptic drugs in human glioblastoma: Pharmacological targets and clinical benefits

M Stella, G Baiardi, S Pasquariello, F Sacco… - Biomedicines, 2023 - mdpi.com
Glioblastoma (GBM) is characterized by fast-growing cells, genetic and phenotypic
heterogeneity, and radio-chemo-therapy resistance, contributing to its dismal prognosis …

The complexities underlying epilepsy in people with glioblastoma

E Sokolov, J Dietrich, AJ Cole - The Lancet Neurology, 2023 - thelancet.com
Seizures are among the most common clinical signs in people with glioblastoma. Advances
over the past 5 years, including new clinical trial data, have increased the understanding of …

Efficacy and tolerability of perampanel in brain tumor-related epilepsy: a systematic review

J Rossi, F Cavallieri, MC Bassi, G Biagini, R Rizzi… - Biomedicines, 2023 - mdpi.com
(1) Background: Epilepsy is a frequent comorbidity in patients with brain tumors, in whom
seizures are often drug-resistant. Current evidence suggests that excess of glutamatergic …

Lacosamide in monotherapy in BTRE (brain tumor-related epilepsy): results from an Italian multicenter retrospective study

F Mo, S Meletti, V Belcastro, S Quadri… - Journal of Neuro …, 2022 - Springer
Purpose Lacosamide (LCM) is a third-generation anti-seizure medication (ASM) approved
for focal onset epilepsy in patients aged≥ 4.378 Previous studies have reported an efficacy …