Injured peripheral nerves but not central nerves have the capacity to regenerate and
reinnervate their target organs. After the two most severe peripheral nerve injuries of six …

Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to
regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow …

The assembly of a new growth cone is a prerequisite for axon regeneration after injury.
Creation of a new growth cone involves multiple processes, including calcium signalling …

Reactivation of a silent transcriptional program is a critical step in successful axon
regeneration following injury. Yet how such a program is unlocked after injury remains …

The extensive lengths of neuronal processes necessitate efficient mechanisms for
communication with the cell body. Neuronal regeneration after nerve injury requires new …

Failure of axon regeneration after central nervous system (CNS) injuries results in
permanent functional deficits. Numerous studies in the past suggested that blocking …

Neurons differ in their responses to injury, but the underlying mechanisms remain poorly
understood. Using quantitative proteomics, we characterized the injury-triggered response …

Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …