The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular
feedback mechanism that interfaces with the genome, consolidating information for …

Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …

Intrinsic disorder (ID) constitutes a new dimension to the protein structure–function
relationship. The ability to undergo conformational changes upon binding is a key property …

To predict transcription, one needs a mechanistic understanding of how the numerous
required transcription factors (TFs) explore the nuclear space to find their target genes …

Intrinsically disordered protein regions (IDRs) pervasively engage in essential molecular
functions, yet they are often poorly conserved as assessed by sequence alignment. To …

The acidic activation domain (AD) of yeast transcription factor Gal4 plays a dual role in
transcription repression and activation through binding to Gal80 repressor and Mediator …

Eukaryotic transcription factors activate gene expression with their DNA-binding domains
and activation domains. DNA-binding domains bind the genome by recognizing structurally …

Intrinsically disordered proteins (IDPs) can be generally described as a class of proteins that
lack a well-defined ordered structure in isolation at physiological conditions. Upon binding to …