Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …

Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

The heart is capable of responding to stressful situations by increasing muscle mass, which
is broadly defined as cardiac hypertrophy. This phenomenon minimizes ventricular wall …

The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli.
p38 function has been studied in depth in relation to cardiac development and function. The …

Objectives: We investigated the effect of reducing mitochondrial oxidative stress by the
mitochondrial-targeted antioxidant peptide SS-31 in hypertensive cardiomyopathy …

Obstructive sleep apnoea syndrome (OSAS) is a highly prevalent disease and is recognised
as a major public health burden. Large-scale epidemiological studies have demonstrated an …

Atrial fibrillation (AF) is the most common supraventricular arrhythmia that, for unknown
reasons, is linked to intense endurance exercise. Our studies reveal that 6 weeks of …

Mitogen-activated protein (MAP) kinases belong to a highly conserved family of Ser-Thr
protein kinases in the human kinome and have diverse roles in broad physiological …

Vitamin D deficiency is highly prevalent worldwide. It has been associated with heart failure
(HF) given its immunoregulatory functions. In-vitro and animal models have shown …

Cardiac failure is a major cause of death in patients with type 2 diabetes, but the molecular
mechanism that links diabetes to heart failure remains unclear. Insulin resistance is a …