The recognition of cellular damage caused by either pathogens or abiotic stress is essential
for host defense in all forms of life in the plant and animal kingdoms. The NOD-like receptors …

DNA methylation is an essential epigenetic mechanism involved in many essential cellular
processes. During development epigenetic reprograming takes place during gametogenesis …

Inflammasomes are multiprotein complexes that drive inflammation and contribute to
protective immunity against pathogens and immune pathology in autoinflammatory …

Background Successful human reproduction requires normal spermatogenesis, oogenesis,
fertilisation and early embryonic development, and abnormalities in any of these processes …

Lymphoma is the most common hematological malignancy in developed countries. Outcome
is strongly determined by molecular subtype, reflecting a need for new and improved …

Before activation of the embryonic genome, the oocyte provides many of the RNAs and
proteins required for the epigenetic reprogramming and the transition to a totipotent state …

Familial recurrent hydatidiform mole (RHM) is a maternal-effect autosomal recessive
disorder usually associated with mutations of the NLRP7 gene. It is characterized by HM …

Eight syndromes are associated with the loss of methylation at specific imprinted loci. There
has been increasing evidence that these methylation defects in patients are not isolated …

Cadmium (Cd) is a widespread heavy metal and a ubiquitous environmental toxicant. For
the general population, the principal causes of Cd exposure are cigarette smoking, air …

Diabetic retinopathy (DR) is an ocular complication of diabetes mellitus (DM). International
Diabetic Federations (IDF) estimates up to 629 million people with DM by the year 2045 …