Cyanotoxins, biosynthetic gene clusters, and factors modulating cyanotoxin biosynthesis

F Bashir, A Bashir, N Bouaïcha, L Chen… - World Journal of …, 2023 - Springer
Cyanobacterial harmful algal blooms (CHABs) are a global environmental concern that
encompasses public health issues, water availability, and water quality owing to the …

[HTML][HTML] The genetic basis of toxin biosynthesis in dinoflagellates

A Verma, A Barua, R Ruvindy, H Savela, PA Ajani… - Microorganisms, 2019 - mdpi.com
In marine ecosystems, dinoflagellates can become highly abundant and even dominant at
times, despite their comparatively slow growth rates. One factor that may play a role in their …

Genomic copy number variability at the genus, species and population levels impacts in situ ecological analyses of dinoflagellates and harmful algal blooms

R Ruvindy, A Barua, CJS Bolch, C Sarowar… - ISME …, 2023 - academic.oup.com
The application of meta-barcoding, qPCR, and metagenomics to aquatic eukaryotic
microbial communities requires knowledge of genomic copy number variability (CNV). CNV …

Plastic-associated harmful microalgal assemblages in marine environment

S Casabianca, S Capellacci, MG Giacobbe… - Environmental …, 2019 - Elsevier
Plastic debris carry fouling a variety of class-size organisms, among them harmful
microorganisms that potentially play a role in the dispersal of allochthonous species and …

First detection of tetrodotoxin and high levels of paralytic shellfish poisoning toxins in shellfish from Sicily (Italy) by three different analytical methods

C Dell'Aversano, L Tartaglione, G Polito, K Dean… - Chemosphere, 2019 - Elsevier
Paralytic shellfish toxins (PST) and tetrodotoxin (TTX) are naturally-occurring toxins that may
contaminate the food chain, inducing similar neurological symptoms in humans. They are co …

[HTML][HTML] Unknown Extracellular and Bioactive Metabolites of the Genus Alexandrium: A Review of Overlooked Toxins

M Long, B Krock, J Castrec, U Tillmann - Toxins, 2021 - mdpi.com
Various species of Alexandrium can produce a number of bioactive compounds, eg,
paralytic shellfish toxins (PSTs), spirolides, gymnodimines, goniodomins, and also …

Paralytic shellfish toxin biosynthesis in cyanobacteria and dinoflagellates: A molecular overview

DZ Wang, SF Zhang, Y Zhang, L Lin - Journal of proteomics, 2016 - Elsevier
Paralytic shellfish toxins (PSTs) are a group of water soluble neurotoxic alkaloids produced
by two different kingdoms of life, prokaryotic cyanobacteria and eukaryotic dinoflagellates …

[HTML][HTML] Biosynthesis of saxitoxin in marine dinoflagellates: An omics perspective

MA Akbar, NY Mohd Yusof, NI Tahir, A Ahmad, G Usup… - Marine drugs, 2020 - mdpi.com
Saxitoxin is an alkaloid neurotoxin originally isolated from the clam Saxidomus giganteus in
1957. This group of neurotoxins is produced by several species of freshwater cyanobacteria …

Temperature influences the content and biosynthesis gene expression of saxitoxins (STXs) in the toxigenic dinoflagellate Alexandrium pacificum

H Wang, H Kim, H Park, JS Ki - Science of The Total Environment, 2022 - Elsevier
Temperature may affect the production of saxitoxin (STX) and its derivatives (STXs);
however, this is still controversial. Further, STX-biosynthesis gene regulation and the …

[HTML][HTML] Low temperature and cold stress significantly increase saxitoxins (STXs) and expression of STX biosynthesis genes sxtA4 and sxtG in the dinoflagellate …

H Kim, H Park, H Wang, HY Yoo, J Park, JS Ki - Marine Drugs, 2021 - mdpi.com
Toxic dinoflagellate Alexandrium spp. produce saxitoxins (STXs), whose biosynthesis
pathway is affected by temperature. However, the link between the regulation of the relevant …