Identifying cognitive and neural mechanisms involved in the development of schizophrenia
requires longitudinal observation of individuals prior to onset. Here recent studies of …

Background Psychosis is a serious mental condition characterised by a loss of contact with
reality. There may be a prodromal period or stage of psychosis, where early signs of …

Importance Altered neurodevelopmental trajectories are thought to reflect heterogeneity in
the pathophysiologic characteristics of schizophrenia, but whether neural indicators of these …

Background: Several cross-sectional studies report brain structure differences between
healthy volunteers and subjects at genetic or clinical high risk of developing schizophrenia …

Although gray matter (GM) abnormalities are present from the early stages of psychosis,
subtle/miniscule changes may not be detected by conventional volumetry. Texture analysis …

The brain ventricular system is a series of connected cavities, filled with cerebrospinal fluid
(CSF), that forms within the vertebrate central nervous system (CNS). The hollow neural tube …

Prediction of psychosis is already possible with an excellent prognostic performance based
on clinical assessments. Recent studies show that this accuracy can be further improved by …

First episode psychosis (FEP), and subsequent diagnosis of schizophrenia or
schizoaffective disorder, predominantly occurs during late adolescence, is accompanied by …

Objective Since the first study published in the Lancet in 1976, structural neuroimaging has
been used in psychosis with the promise of imminent clinical utility. The actual impact of …

Neuroimaging studies have identified patterns of brain abnormalities in various stages of
schizophrenia, but whether these abnormalities reflect primary factors associated with the …