A comprehensive overview of Artemisinin and its derivatives as anticancer agents

Z Zeng, D Chen, L Chen, B He, Y Li - European Journal of Medicinal …, 2023 - Elsevier
Artemisinin is the crucial ingredient of artemisia annua, a traditional Chinese medicine used
for the therapy of malaria in China for hundreds of years. In recent years, the anticancer …

Molecular hybridization as a strategy for developing artemisinin-derived anticancer candidates

E Marchesi, D Perrone, ML Navacchia - Pharmaceutics, 2023 - mdpi.com
Artemisinin is a natural compound extracted from Artemisia species belonging to the
Asteraceae family. Currently, artemisinin and its derivatives are considered among the most …

Drug Repurposing‐Based Brain‐Targeting Self‐Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma

J Liang, L Li, H Tian, Z Wang, G Liu, X Duan, M Guo… - Small, 2023 - Wiley Online Library
Glioblastoma (GBM), the most aggressive and lethal form of malignant brain tumor, is a
therapeutic challenge due to the drug filtration capabilities of the blood‐brain barrier (BBB) …

Folic Acid–Modified Long-Circulating Liposomes Loaded with Sulfasalazine For Targeted Induction of Ferroptosis in Melanoma

D Zhang, M Zhang, Y Pang, M Li… - ACS Biomaterials Science …, 2023 - ACS Publications
Melanoma is a malignant tumor that originates from melanocytes. The incidence of
melanoma is increasing worldwide, partially because of its insensitivity to radiotherapy or …

Access to Artemisinin–Triazole Antimalarials via Organo-Click Reaction: High In Vitro/In Vivo Activity against Multi-Drug-Resistant Malaria Parasites

L Herrmann, M Leidenberger, HC Quadros, BW Grau… - JACS Au, 2024 - ACS Publications
Malaria is one of the most widespread diseases worldwide. Besides a growing number of
people potentially threatened by malaria, the consistent emergence of resistance against …

Mitochondrial regulation of ferroptosis in cancer therapy

X Cheng, J Zhang, Y Xiao, Z Wang, J He, M Ke… - International Journal of …, 2023 - mdpi.com
Ferroptosis, characterized by glutamate overload, glutathione depletion, and
cysteine/cystine deprivation during iron-and oxidative-damage-dependent cell death, is a …

The current scenario on anticancer activity of artemisinin metal complexes, hybrids, and dimers

S Zhang, C Yi, WW Li, Y Luo, YZ Wu… - Archiv der …, 2022 - Wiley Online Library
Cancer, the most significant cause of morbidity and mortality, has already posed a heavy
burden on health care systems globally. In recent years, cancer treatment has made a …

Ferroptosis in glioma treatment: Current situation, prospects and drug applications

Y Zhou, C Fang, H Xu, L Yuan, Y Liu, X Wang… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis is a regulatory form of iron-dependent cell death caused by the accumulation of
lipid-based reactive oxygen species (ROS) and differs from apoptosis, pyroptosis, and …

A Domino [3+ 2] Cycloaddition/Deamination/Imine Hydrolysis Reaction of Cyclopropyl Spirooxindoles with Thiourea for Access to Spiro-γ-thiolactone oxindoles

HT Wang, XL Wen, XL Xu, DC Wang… - Organic Chemistry …, 2024 - pubs.rsc.org
An efficient method for a domino [3+ 2] cycloaddition/deamination/imine hydrolysis reaction
of DA cyclopropane with inexpensive thiourea catalyzed by Lu (OTf) 3 has been developed …

Synthesis of oxazole–tetrahydropyran hybrids and study on their antiproliferative activity against human tumour cells

V Quintana, A González‐Bakker… - European Journal of …, 2022 - Wiley Online Library
A series of triazole linked tetrahydropyran–oxazole hybrids was synthesized based on a
previously reported lead compound with selective antiproliferative activity against human …