An update on diagnostic and prognostic biomarkers for traumatic brain injury

KK Wang, Z Yang, T Zhu, Y Shi… - Expert review of …, 2018 - Taylor & Francis
Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …

Fluid biomarkers for mild traumatic brain injury and related conditions

H Zetterberg, K Blennow - Nature reviews neurology, 2016 - nature.com
Diagnostic and prognostic biomarkers for mild traumatic brain injury (TBI), also known as
concussion, remain a major unmet clinical need. Moderate to severe TBI can be diagnosed …

Military traumatic brain injury: a challenge straddling neurology and psychiatry

LZ Kong, RL Zhang, SH Hu, JB Lai - Military medical research, 2022 - Springer
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible
effect of the war. In this review, we begin by examining related military research …

Plasma biomarkers of brain injury in neonatal hypoxic-ischemic encephalopathy

AN Massaro, YW Wu, TK Bammler, B Comstock… - The Journal of …, 2018 - Elsevier
Objectives To evaluate plasma brain specific proteins and cytokines as biomarkers of brain
injury in newborns with hypoxic-ischemic encephalopathy (HIE) and, secondarily, to assess …

Moderate traumatic brain injury alters the gastrointestinal microbiome in a time-dependent manner

SE Nicholson, LT Watts, DM Burmeister, D Merrill… - Shock, 2019 - journals.lww.com
The microbiome is defined as the collective genomes of the microbes (composed of
bacteria, bacteriophage, fungi, protozoa, and viruses) that colonize the human body, and …

Neurochemical biomarkers in spinal cord injury

BK Kwon, O Bloom, IB Wanner, A Curt, JM Schwab… - Spinal Cord, 2019 - nature.com
Study design This is a narrative review of the literature on neurochemical biomarkers in
spinal cord injury (SCI). Objectives The objective was to summarize the literature on …

Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: recent developments

H Zhao, A Alam, CY San, S Eguchi, Q Chen, Q Lian… - Brain research, 2017 - Elsevier
Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a
significant cause of mortality around the world. On a molecular level, the condition is …

Longitudinal associations between persistent post-concussion symptoms and blood biomarkers of inflammation and CNS-Injury after mild traumatic brain Injury

GJB Clarke, T Skandsen, H Zetterberg… - Journal of …, 2024 - liebertpub.com
The aim of our study was to investigate the biological underpinnings of persistent post-
concussion symptoms (PPCS) at 3 months following mild traumatic brain injury (mTBI) …

Neuroprotective and Anti‐inflammatory Effects of Pioglitazone on Traumatic Brain Injury

MY Zamanian, N Taheri, MJC Opulencia… - Mediators of …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is still a major cause of concern for public health, and out of all
the trauma‐related injuries, it makes the highest contribution to death and disability …

Performance evaluation of a multiplex assay for simultaneous detection of four clinically relevant traumatic brain injury biomarkers

FK Korley, JK Yue, DH Wilson, K Hrusovsky… - Journal of …, 2019 - liebertpub.com
Traumatic brain injury (TBI) results in heterogeneous pathology affecting multiple cells and
tissue types in the brain. It is likely that assessment of such complexity will require …