Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …

Alternative polyadenylation (APA) is a major driver of transcriptome diversity in human cells.
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …

The RNA recognition motif (RRM), also known as RNA‐binding domain (RBD) or
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …

Through alternative polyadenylation, human mRNAs acquire longer or shorter 3′
untranslated regions, the latter typically associated with higher transcript stability and …

Abstract The coronavirus disease‐2019 (COVID‐19) pandemic caused by severe acute
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has already resulted in a huge setback …

ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …

TDP-43 is a highly conserved nuclear factor of yet unknown function that binds to ug-
repeated sequences and is responsible for cystic fibrosis transmembrane conductance …

Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …

Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …