[HTML][HTML] 3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
RNA-binding proteins: modular design for efficient function
BM Lunde, C Moore, G Varani - Nature reviews Molecular cell biology, 2007 - nature.com
Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …
of just a few basic domains that are arranged in various ways to satisfy their diverse …
[HTML][HTML] A deep neural network for predicting and engineering alternative polyadenylation
Alternative polyadenylation (APA) is a major driver of transcriptome diversity in human cells.
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …
The RNA recognition motif, a plastic RNA‐binding platform to regulate post‐transcriptional gene expression
C Maris, C Dominguez, FHT Allain - The FEBS journal, 2005 - Wiley Online Library
The RNA recognition motif (RRM), also known as RNA‐binding domain (RBD) or
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …
[HTML][HTML] Genome-wide analysis of pre-mRNA 3′ end processing reveals a decisive role of human cleavage factor I in the regulation of 3′ UTR length
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3′
untranslated regions, the latter typically associated with higher transcript stability and …
untranslated regions, the latter typically associated with higher transcript stability and …
In silico analyses on the comparative sensing of SARS‐CoV‐2 mRNA by the intracellular TLRs of humans
Abstract The coronavirus disease‐2019 (COVID‐19) pandemic caused by severe acute
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has already resulted in a huge setback …
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has already resulted in a huge setback …
Molecular mechanisms of eukaryotic pre-mRNA 3′ end processing regulation
S Millevoi, S Vagner - Nucleic acids research, 2010 - academic.oup.com
ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …
[HTML][HTML] TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane …
E Buratti, A Brindisi, M Giombi, S Tisminetzky… - Journal of Biological …, 2005 - ASBMB
TDP-43 is a highly conserved nuclear factor of yet unknown function that binds to ug-
repeated sequences and is responsible for cystic fibrosis transmembrane conductance …
repeated sequences and is responsible for cystic fibrosis transmembrane conductance …
Protein factors in pre-mRNA 3′-end processing
CR Mandel, Y Bai, L Tong - Cellular and Molecular Life Sciences, 2008 - Springer
Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …
Cleavage and polyadenylation: Ending the message expands gene regulation
J Neve, R Patel, Z Wang, A Louey, AM Furger - RNA biology, 2017 - Taylor & Francis
Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
of primary protein encoding transcripts into functional mRNAs that can be exported from the …