Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway

JM Rojas, A Alejo, V Martín, N Sevilla - Cellular and Molecular Life …, 2021 - Springer
Antiviral responses of interferons (IFNs) are crucial in the host immune response, playing a
relevant role in controlling viralw infections. Three types of IFNs, type I (IFN-α, IFN-β), II (IFN …

Epizootic hemorrhagic disease virus: Current knowledge and emerging perspectives

L Jiménez-Cabello, S Utrilla-Trigo, G Lorenzo, J Ortego… - Microorganisms, 2023 - mdpi.com
Epizootic Hemorrhagic Disease (EHD) of ruminants is a viral pathology that has significant
welfare, social, and economic implications. The causative agent, epizootic hemorrhagic …

The A137R protein of African swine fever virus inhibits type I interferon production via the autophagy-mediated lysosomal degradation of TBK1

M Sun, S Yu, H Ge, T Wang, Y Li, P Zhou, L Pan… - Journal of …, 2022 - Am Soc Microbiol
African swine fever is a lethal hemorrhagic disease of pigs caused by African swine fever
virus (ASFV), which greatly threatens the pig industry in many countries. Deletion of …

Bluetongue virus serotype 27: detection and characterization of two novel variants in Corsica, France

C Schulz, E Bréard, C Sailleau… - Journal of General …, 2016 - microbiologyresearch.org
During the compulsory vaccination programme against bluetongue virus serotype 1 (BTV-1)
in Corsica (France) in 2014, a BTV strain belonging to a previously uncharacterized …

[HTML][HTML] Importance of viral disease in dairy cow fertility

DC Wathes, CF Oguejiofor, C Thomas, Z Cheng - Engineering, 2020 - Elsevier
Many viral diseases are endemic in cattle populations worldwide. The ability of many viruses
to cross the placenta and cause abortions and fetal malformations is well understood. There …

Bluetongue virus: from BTV-1 to BTV-27

G Belbis, S Zientara, E Breard, C Sailleau… - Advances in Virus …, 2017 - Elsevier
Bluetongue virus (BTV) is the type species of genus Orbivirus within family Reoviridae.
Bluetongue virus is transmitted between its ruminant hosts by the bite of Culicoides spp …

Prospects of next-generation vaccines for bluetongue

PA Van Rijn - Frontiers in Veterinary Science, 2019 - frontiersin.org
Bluetongue (BT) is a haemorrhagic disease of wild and domestic ruminants with a huge
economic worldwide impact on livestock. The disease is caused by BT-virus transmitted by …

Virus‐induced autophagic degradation of STAT 2 as a mechanism for interferon signaling blockade

M Avia, JM Rojas, L Miorin, E Pascual, PA Van Rijn… - EMBO …, 2019 - embopress.org
The mammalian interferon (IFN) signaling pathway is a primary component of the innate
antiviral response, and viral pathogens have evolved multiple mechanisms to antagonize …

Mammalian adaptation of an avian influenza A virus involves stepwise changes in NS1

C Chauche, A Nogales, H Zhu, D Goldfarb… - Journal of …, 2018 - Am Soc Microbiol
Influenza A viruses (IAVs) are common pathogens of birds that occasionally establish
endemic infections in mammals. The processes and mechanisms that result in IAV …

Follicular dendritic cell disruption as a novel mechanism of virus-induced immunosuppression

E Melzi, M Caporale, M Rocchi… - Proceedings of the …, 2016 - National Acad Sciences
Arboviruses cause acute diseases that increasingly affect global health. We used
bluetongue virus (BTV) and its natural sheep host to reveal a previously uncharacterized …