Recent work in structural biology is shedding light on how many of the enzymes of
intermediary metabolism are self-and co-assembling into large, filamentous polymers or …

Oligomeric proteins are central to cellular life and the duplication and divergence of their
genes is a key driver of evolutionary innovations. The duplication of a gene coding for an …

The evolution of novel functions in biology relies heavily on gene duplication and
divergence, creating large paralogous protein families. Selective pressure to avoid …

Oligomerization is a core structural feature that defines the form and function of many
proteins. Most proteins form molecular complexes; however, there remains a dearth of …

This study explores the implications of a novel germline missense mutation (R38C) in the
succinate dehydrogenase (SDH) subunit B, which has been linked to neurodegenerative …

Cystathionine beta-synthase (CBS) is an essential metabolic enzyme across all domains of
life for the production of glutathione, cysteine, and hydrogen sulfide. Appended to the …

Developing protein confinement platforms is an attractive research area that not only
promotes protein delivery but also can result in artificial environment mimicking of the …

It has been recently suggested that a significant fraction of homomer protein–protein
interfaces evolve neutrally, without contributing to function, due to a hydrophobic bias in …

The stabilization of natural proteins is a long‐standing desired goal in protein engineering.
Optimizing the hydrophobicity of the protein core often results in extensive stability …

Manganese peroxidase (MnP), a vital extracellular enzyme for the degradation of lignin and
other organic pollutants, has demonstrated immense potential for agricultural and …