Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now
known to represent a distinct member of the IFN family and plays critical roles not only in …

Periodontal diseases usually refer to common inflammatory disorders known as gingivitis
and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm …

Purpose Classical Hodgkin lymphoma (HL) frequently exhibits genetic alterations leading to
overexpression of the programmed death-1 (PD-1) ligands, suggesting a possible …

The significance of the essential trace element zinc for immune function has been known for
several decades. Zinc deficiency affects immune cells, resulting in altered host defense …

Background The generation of interferon-gamma (IFN-γ) by MHC class II activated CD4+ T
helper cells play a substantial contribution in the control of infections such as caused by …

Interferon-γ is a cytokine whose biological activity is conventionally associated with
cytostatic/cytotoxic and antitumor mechanisms during cell-mediated adaptive immune …

The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …

Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the
destruction of tooth-supporting structures, being the presence of periodontopathogens …

As acute infections resolve, effector CD8+ T cells differentiate into interleukin-7 receptor lo
(IL-7R lo) short-lived effector cells (SLECs) and IL-7R hi memory precursor effector cells …

Human and mouse plasmacytoid dendritic cells have been shown to correspond to a
specialized cell population that produces large amounts of type I interferons in response to …