Natural products targeting cancer cell dependency
C Shi, EJ Yang, S Tao, G Ren, PK Mou… - The Journal of …, 2021 - nature.com
Precision cancer medicine is a tailored treatment approach for individual cancer patients
with different genomic characteristics. Mutated or hyperactive oncogenes have served as …
with different genomic characteristics. Mutated or hyperactive oncogenes have served as …
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
J Martino, SO Siri, NL Calzetta, NS Paviolo, C Garro… - Elife, 2023 - elifesciences.org
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors
(PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient …
(PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient …
Regioselective synthetic approach for key precursors of 6-arylbenzo [c] phenanthridin-10-ol derivatives: a useful compound for selective chromogenic recognition of …
A regioselective synthetic strategy for 6-aryl-8, 9-dihydrobenzo [c] phenanthridine-10 (7H)-
ones (4) is accomplished using a one-pot four-component reaction by fine-tuning the …
ones (4) is accomplished using a one-pot four-component reaction by fine-tuning the …
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency
L Guantay, C Garro, S Siri, MF Pansa… - Drug Resistance …, 2023 - Elsevier
BRCA2 is a well-established cancer driver in several human malignancies. While the
remarkable success of PARP inhibitors proved the clinical potential of targeting BRCA …
remarkable success of PARP inhibitors proved the clinical potential of targeting BRCA …
Inhibitors of ROCK kinases induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
J Martino, SO Siri, NS Paviolo, C Garro, MF Pansa… - bioRxiv, 2022 - biorxiv.org
BRCA2-deficient cells are highly sensitive to poly-ADP-ribose polymerase inhibitors (PARPi)
due to their impaired homologous recombination repair. This increased cytotoxicity is …
due to their impaired homologous recombination repair. This increased cytotoxicity is …