In the last few years, more and more scientists have suggested and confirmed that
epigenetic regulators are tightly connected and form a comprehensive network of regulatory …

Whole-genome sequencing data mining efforts have revealed numerous histone mutations
in a wide range of cancer types. These occur in all four core histones in both the tail and …

Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a
classic marker for heterochromatin. HP1 binds to di-and tri-methylated histone H3K9 and …

Stalk-eyed flies in the genus Teleopsis carry selfish genetic elements that induce sex ratio
(SR) meiotic drive and impact the fitness of male and female carriers. Here, we assemble …

Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is
interpreted by epigenetic readers that assist transcription and safeguard the integrity of the …

Aging is a multifactorial process that disturbs homeostasis, increases disease susceptibility,
and ultimately results in death. Although the definitive set of molecular mechanisms …

Extracellular signals are transmitted through kinase cascades to modulate gene expression,
but it remains unclear how epigenetic changes regulate this response. Here, we provide …

Animals use the Polycomb system to epigenetically repress developmental genes. The
repression requires trimethylation of lysine 27 of histone H3 (H3K27me3) by Polycomb …

Background Cells orchestrate histone biogenesis with strict temporal and quantitative
control. To efficiently regulate histone biogenesis, the repetitive Drosophila melanogaster …

Histone acetylation and deposition of H2A. Z variant are integral aspects of active
transcription. In Drosophila, the single DOMINO chromatin regulator complex is thought to …