The NRF2, thioredoxin, and glutathione system in tumorigenesis and anticancer therapies
Cancer remains an elusive, highly complex disease and a global burden. Constant change
by acquired mutations and metabolic reprogramming contribute to the high inter-and …
by acquired mutations and metabolic reprogramming contribute to the high inter-and …
Oncolytic viro-immunotherapy: an emerging option in the treatment of gliomas
J Zeng, X Li, M Sander, H Zhang, G Yan… - Frontiers in …, 2021 - frontiersin.org
The prognosis of malignant gliomas remains poor, with median survival fewer than 20
months and a 5-year survival rate merely 5%. Their primary location in the central nervous …
months and a 5-year survival rate merely 5%. Their primary location in the central nervous …
Directed evolution of adeno-associated virus for efficient gene delivery to microglia
As the resident immune cells in the central nervous system (CNS), microglia orchestrate
immune responses and dynamically sculpt neural circuits in the CNS. Microglial dysfunction …
immune responses and dynamically sculpt neural circuits in the CNS. Microglial dysfunction …
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether
microglial subsets characterized by the expression of specific proteins constitute subtypes …
microglial subsets characterized by the expression of specific proteins constitute subtypes …
Enhancing antibody-dependent cellular phagocytosis by Re-education of tumor-associated macrophages with resiquimod-encapsulated liposomes
Tumor-associated macrophages (TAMs) exist in nearly all tumors, and form a major part of
the tumor microenvironment. TAMs are divided into two groups: tumor-suppressing M1 type …
the tumor microenvironment. TAMs are divided into two groups: tumor-suppressing M1 type …
Interactions between tumor cells, neurons, and microglia in the glioma microenvironment
Despite significant strides made in understanding the pathophysiology of high-grade
gliomas over the past two decades, most patients succumb to these neoplasias within two …
gliomas over the past two decades, most patients succumb to these neoplasias within two …
Oxidants, antioxidants and thiol redox switches in the control of regulated cell death pathways
M Benhar - Antioxidants, 2020 - mdpi.com
It is well appreciated that biological reactive oxygen and nitrogen species such as hydrogen
peroxide, superoxide and nitric oxide, as well as endogenous antioxidant systems, are …
peroxide, superoxide and nitric oxide, as well as endogenous antioxidant systems, are …
The microbiota–microglia axis in central nervous system disorders
The innate immune system in the central nervous system (CNS) is mainly represented by
specialized tissue‐resident macrophages, called microglia. In the past years, various …
specialized tissue‐resident macrophages, called microglia. In the past years, various …
TET2 regulates the neuroinflammatory response in microglia
A Carrillo-Jimenez, Ö Deniz, MV Niklison-Chirou… - Cell reports, 2019 - cell.com
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune
cells. Despite the central role for microglia in neuroinflammation and neurodegeneration …
cells. Despite the central role for microglia in neuroinflammation and neurodegeneration …
The role of myeloid cells in GBM immunosuppression
Gliomas are intrinsic brain tumors that originate from glial cells. Glioblastoma (GBM) is the
most aggressive glioma type and resistant to immunotherapy, mainly due to its unique …
most aggressive glioma type and resistant to immunotherapy, mainly due to its unique …