β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East Asians

D Yabe, Y Seino, M Fukushima, S Seino - Current diabetes reports, 2015 - Springer
Abstract Type 2 diabetes (T2DM) is one of the most serious global health problems and is
mainly a result of the drastic increase in East Asia, which includes over a fourth of the global …

Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health

JF Millman, S Okamoto, T Teruya, T Uema… - Nutrition …, 2021 - academic.oup.com
Extra-virgin olive oil (EVOO), a popular functional food and major source of fat in the
Mediterranean diet, possesses a variety of healthful components, including …

Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre …

N Inagaki, M Takeuchi, T Oura, T Imaoka… - The Lancet Diabetes & …, 2022 - thelancet.com
Background As the disease progresses, many patients with type 2 diabetes have difficulty in
reaching treatment goals. We aimed to assess the efficacy and safety of tirzepatide, a novel …

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active …

JP Frias, MA Nauck, J Van, ME Kutner, X Cui… - The Lancet, 2018 - thelancet.com
Background LY3298176 is a novel dual glucose-dependent insulinotropic polypeptide (GIP)
and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the …

Incretin‐based drugs for type 2 diabetes: focus on East Asian perspectives

Y Seino, H Kuwata, D Yabe - Journal of diabetes investigation, 2016 - Wiley Online Library
Abstract Type 2 diabetes in East Asians is characterized primarily by β‐cell dysfunction, and
with less adiposity and less insulin resistance compared with that in Caucasians. Such …

β-cell fate in human insulin resistance and type 2 diabetes: a perspective on islet plasticity

T Mezza, F Cinti, CMA Cefalo, A Pontecorvi… - Diabetes, 2019 - Am Diabetes Assoc
Although it is well established that type 2 diabetes (T2D) is generally due to the progressive
loss of β-cell insulin secretion against a background of insulin resistance, the actual …

[HTML][HTML] Current findings on the efficacy of incretin-based drugs for diabetic kidney disease: a narrative review

A Mima, A Nomura, T Fujii - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Diabetic kidney disease (DKD) is the most common cause of chronic kidney disease (CKD),
leading end-stage renal disease. Thus, DKD is one of the most important diabetic …

Endothelial dysfunction in diabetes

Y Takeda, K Matoba, K Sekiguchi, Y Nagai, T Yokota… - Biomedicines, 2020 - mdpi.com
Diabetes is a worldwide health issue closely associated with cardiovascular events. Given
the pandemic of obesity, the identification of the basic underpinnings of vascular disease is …

Nutritional and therapeutic perspectives of camel milk and its protein hydrolysates: A review on versatile biofunctional properties

A Izadi, L Khedmat, SY Mojtahedi - Journal of Functional Foods, 2019 - Elsevier
This updated review summarizes the available literature on major bio-functionalities of Ca-M
and its protein hydrolysates such as antimicrobial, antioxidant, antiradical, antidiabetic …

Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions

D Nasteska, N Harada, K Suzuki, S Yamane… - Diabetes, 2014 - Am Diabetes Assoc
Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and
anabolic effects on bone formation and fat accumulation. We explored the impact of reduced …