Laboratory mouse models offer opportunities to bridge the gap between basic neuroscience
and applied stress research. Here we consider the ecological validity of social defeat …

Background Emerging evidence points to a central role of mitochondria in psychiatric
disorders. However, little is known about the molecular players that regulate mitochondria in …

Connexins (Cxs) are a family of 21 protein isoforms, eleven of which are expressed in the
central nervous system, and they are found in neurons and glia. Cxs form hemichannels …

Background: The nucleus accumbens (NAcc) is a crucial brain region for emotionally
relevant behaviours. The NAcc is mainly composed of medium spiny neurons (MSNs) …

Individual differences in anxiety provide a differential predisposition to develop
neuropsychiatric disorders. The neurochemical underpinnings of anxiety remain elusive …

Background: Stress-related obesity might be related to the suppression of the hypothalamic-
pituitary-adrenocortical axis and dysregulation of the metabolic system. Chronic stress also …

Early life adversity can disrupt development leading to emotional and cognitive disorders.
This study investigated the effects of social isolation after weaning on anxiety, body weight …

Anxiety is presumably driven by fear memory. The nucleus accumbens involves emotional
regulation. Molecular profiles in the nucleus accumbens related to stress-induced fear …

Exposure to stressful experiences accounts for almost half of the risk for mental disorders.
Hence, stress-induced alterations represent a key target for pharmacological interventions …

Mefloquine, a potent blood schizontocide, is effective against drug-resistant Plasmodium
falciparum. This property, along with its unique pharmacokinetic profile, makes mefloquine a …