It is well-established that the chemokine CXC motif ligand 13 (CXCL13) and its receptor, the
G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …

Pathologic T cell–B cell interactions underlie many autoimmune diseases. The T cells that
help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical …

During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …

The memory T cell pool functions as a dynamic repository of antigen-experienced T
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …

Japan residues, CXC and CC, depending on whether the first two cysteine residues have an
amino acid between them Chemokines are a group of small (8–14 kDa), mostly(CXC) or are …

The proper function of immune surveillance requires well-coordinated mechanisms in order
to guide the patrolling immune cells through peripheral tissues and into secondary lymphoid …

Monocytes recruited to tissues mediate defense against microbes or contribute to
inflammatory diseases. Regulation of the number of circulating monocytes thus has …