The nucleosomal subunit organization of chromatin provides a multitude of functions.
Nucleosomes elicit an initial∼ 7-fold linear compaction of genomic DNA. They provide a …

This article reviews the effects of the short-chain fatty acid butyrate on histone deacetylase
(HDAC) activity. Sodium butyrate has multiple effects on cultured mammalian cells that …

The organization of eukaryotic chromatin has a major impact on all nuclear processes
involving DNA substrates. Gene expression is affected by the positioning of individual …

Post-translational addition of methyl groups to the amino-terminal tails of histone proteins
was discovered more than three decades ago. Only now, however, is the biological …

The core histone tails are critical in chromatin structure and signaling. Studies over the past
several decades have provided a wealth of information on the histone tails and their …

▪ Abstract Chromatin fibers are dynamic macromolecular assemblages that are intimately
involved in nuclear function. This review focuses on recent advances centered on the …

Understanding signaling and other complex biological processes requires elucidating the
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …

BACKGROUND Over the past few years, advances in molecular technologies have allowed
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …

Abstract DIM-5 is a SUV39-type histone H3 Lys9 methyltransferase that is essential for DNA
methylation in N. crassa. We report the structure of a ternary complex including DIM-5, S …

The N-terminal tail of histone H4 is an indispensable mediator for inter-nucleosome
interaction, which is required for chromatin fiber condensation. H4K16 acetylation …