Molecular and evolutionary processes generating variation in gene expression
Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …
variation arises from mutations that alter the form or function of molecular gene regulatory …
[HTML][HTML] Evolution of genetic networks for human creativity
The genetic basis for the emergence of creativity in modern humans remains a mystery
despite sequencing the genomes of chimpanzees and Neanderthals, our closest hominid …
despite sequencing the genomes of chimpanzees and Neanderthals, our closest hominid …
The evolution, evolvability and engineering of gene regulatory DNA
Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …
Comparative studies of gene expression and the evolution of gene regulation
The hypothesis that differences in gene regulation have an important role in speciation and
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …
Detecting signatures of selection on gene expression
A substantial amount of phenotypic diversity results from changes in gene expression levels
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …
Revealing the architecture of gene regulation: the promise of eQTL studies
Expression quantitative trait loci (eQTL) mapping studies have become a widely used tool
for identifying genetic variants that affect gene regulation. In these studies, expression levels …
for identifying genetic variants that affect gene regulation. In these studies, expression levels …
Gene regulation and speciation
KL Mack, MW Nachman - Trends in Genetics, 2017 - cell.com
Understanding the genetic architecture of speciation is a major goal in evolutionary biology.
Hybrid dysfunction is thought to arise most commonly through negative interactions between …
Hybrid dysfunction is thought to arise most commonly through negative interactions between …
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
X Liu, M Somel, L Tang, Z Yan, X Jiang, S Guo… - Genome …, 2012 - genome.cshlp.org
Over the course of ontogenesis, the human brain and human cognitive abilities develop in
parallel, resulting in a phenotype strikingly distinct from that of other primates. Here, we used …
parallel, resulting in a phenotype strikingly distinct from that of other primates. Here, we used …
Sex-specific and lineage-specific alternative splicing in primates
Comparative studies of gene regulation suggest an important role for natural selection in
shaping gene expression patterns within and between species. Most of these studies …
shaping gene expression patterns within and between species. Most of these studies …
Genetic basis of fitness differences in natural populations
H Ellegren, BC Sheldon - Nature, 2008 - nature.com
Genomics profoundly influences current biology. One of many exciting consequences of this
revolution is the potential for identifying and studying the genetic basis of those traits …
revolution is the potential for identifying and studying the genetic basis of those traits …