The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia
As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
Extracellular matrix remodelling in obesity and metabolic disorders
Obesity causes extracellular matrix (ECM) remodelling which can develop into serious
pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM …
pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM …
Insulin, muscle glucose uptake, and hexokinase: revisiting the road not taken
DH Wasserman - Physiology, 2022 - journals.physiology.org
Research conducted over the last 50 yr has provided insight into the mechanisms by which
insulin stimulates glucose transport across the skeletal muscle cell membrane Transport …
insulin stimulates glucose transport across the skeletal muscle cell membrane Transport …
Hepatic alterations during the development and progression of cancer cachexia
ME Rosa-Caldwell, JL Brown, DE Lee… - Applied Physiology …, 2020 - cdnsciencepub.com
Cancer-associated bodyweight loss (cachexia) is a hallmark of many cancers and is
associated with decreased quality of life and increased mortality. Hepatic function can …
associated with decreased quality of life and increased mortality. Hepatic function can …
Implications of skeletal muscle extracellular matrix remodeling in metabolic disorders: diabetes perspective
K Ahmad, I Choi, YH Lee - International journal of molecular sciences, 2020 - mdpi.com
The extracellular matrix (ECM) provides a scaffold for cells, controlling biological processes
and providing structural as well as mechanical support to surrounding cells. Disruption of …
and providing structural as well as mechanical support to surrounding cells. Disruption of …
Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake
F Draicchio, V Behrends, NA Tillin… - The Journal of …, 2022 - Wiley Online Library
Whole‐body euglycaemia is partly maintained by two cellular processes that encourage
glucose uptake in skeletal muscle, the insulin‐and contraction‐stimulated pathways, with …
glucose uptake in skeletal muscle, the insulin‐and contraction‐stimulated pathways, with …
Local ancestry and selection in admixed Sanjiang cattle
Y Lyu, Y Ren, K Qu, S Quji, B Zhuzha, C Lei, N Chen - Stress Biology, 2023 - Springer
The majority of native cattle are taurine× indicine cattle of diverse phenotypes in the central
region of China. Sanjiang cattle, a typical breed in the central region, play a central role in …
region of China. Sanjiang cattle, a typical breed in the central region, play a central role in …
[HTML][HTML] Adipocyte integrin-linked kinase plays a key role in the development of diet-induced adipose insulin resistance in male mice
AR Bugler-Lamb, A Hasib, X Weng, CK Hennayake… - Molecular …, 2021 - Elsevier
Objective Increased deposition of the extracellular matrix (ECM) in adipose tissue (AT)
during obesity contributes to insulin resistance. The integrin receptors transmit changes in …
during obesity contributes to insulin resistance. The integrin receptors transmit changes in …
Link between insulin resistance and skeletal muscle extracellular matrix remodeling
R Aleksandrowicz, M Strączkowski - Endocrine Connections, 2023 - ec.bioscientifica.com
Skeletal muscle is the main metabolic tissue responsible for glucose homeostasis in the
body. It is surrounded by the extracellular matrix (ECM) consisting of three layers …
body. It is surrounded by the extracellular matrix (ECM) consisting of three layers …
Association of single nucleotide polymorphisms with insulin secretion, insulin sensitivity, and diabetes in women with a history of gestational diabetes mellitus
RB Prasad, K Kristensen, A Katsarou, N Shaat - BMC Medical Genomics, 2021 - Springer
Background This study investigated whether single nucleotide polymorphisms (SNPs)
reported by previous genome-wide association studies (GWAS) to be associated with …
reported by previous genome-wide association studies (GWAS) to be associated with …