The four Janus kinase (JAK) proteins and the seven Signal Transducers of Activated
Transcription (STAT) mediate intracellular signal transduction downstream of cytokine …

Vasculitis is an inflammation of the blood vessels caused by autoimmunity and/or
autoinflammation, and recent advances in research have led to a better understanding of its …

Takayasu Arteritis (TAK) is a large-vessel vasculitis that preferentially involves the aorta and
its primary branches. Cardiac involvement is frequent in TAK and is a major determinant of …

Objectives Molecular mechanisms underlying large-vessel involvement in giant cell arteritis
(LV-GCA) are largely unknown. Herein, we explore the critical involvement of pro …

ABSTRACT Introduction Janus kinase inhibitors (JAKi) have dramatically improved the
treatment of various autoimmune and myeloproliferative disorders. Recently, concern has …

Behçet's disease is a rare and poorly understood vasculitis affecting blood vessels of all
types and sizes. Uveitis and oral and genital ulcers represent the typical clinical triad …

Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased
risk of coronary heart disease and is the most common cause of acquired heart disease in …

Giant cell arteritis is the most common vasculitis in adults above 50 years old. The disease is
characterized by granulomatous inflammation of medium and large arteries, particularly the …

Behçet's disease (BD) is a systemic vasculitis that can affect multiple systems, including the
skin, mucous membranes, joints, eyes, gastrointestinal and nervous. However, the …

Objective The pilot study aims to evaluate the effectiveness and safety of baricitinib in
Behcet's Disease (BD) patients with refractory vascular involvement. Methods We …